![]() ![]() To advance mechanistic understanding, we rationalise 13 reasons why the brain is susceptible to oxidative stress. Using free radicals and non-radical derivatives to signal sensitises the brain to oxidative stress when redox signalling goes awry (i.e. synaptic plasticity) through redox signalling (i.e. To understand how many reasons underpin oxidative stress, one must first re-cast free radical and non-radical species in a positive light because their deliberate generation enables the brain to achieve critical functions (e.g. ![]() Many are erroneously understood as the deleterious result of adventitious O 2 derived free radical and non-radical species generation. Ambiguity exists because many of the reasons why the brain is susceptible to oxidative stress remain obscure. While the essentiality of O 2 to brain function is clear, how oxidative stress causes neurodegeneration is ambiguous. ![]() Without sufficient O 2 to support ATP demands, neuronal activity fails, such that, even transient ischemia is neurodegenerative. The human brain consumes 20% of the total basal oxygen (O 2) budget to support ATP intensive neuronal activity.
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